PittsburghV1, Main, Exploration, bibRecord, 003F68

Amelioration of Radiation-Induced Oral Cavity Mucositis and Distant Bone Marrow Suppression in Fanconi Anemia Fancd2−/− (FVB/N) Mice by Intraoral GS-Nitroxide JP4-039

Identifieur interne : 003F68 ( Main/Exploration ); précédent : 003F67; suivant : 003F69

Amelioration of Radiation-Induced Oral Cavity Mucositis and Distant Bone Marrow Suppression in Fanconi Anemia Fancd2−/− (FVB/N) Mice by Intraoral GS-Nitroxide JP4-039

Auteurs : Hebist Berhane [États-Unis] ; Ashwin Shinde [États-Unis] ; Ronny Kalash [États-Unis] ; Karen Xu [États-Unis] ; Michael W. Epperly [États-Unis] ; Julie Goff [États-Unis] ; Darcy Franicola [États-Unis] ; Xichen Zhang [États-Unis] ; Tracy Dixon [États-Unis] ; Donna Shields [États-Unis] ; Hong Wang [États-Unis] ; Peter Wipf [États-Unis] ; Song Li [États-Unis] ; Xiang Gao [États-Unis] ; Joel S. Greenberger [États-Unis]

Source :

Radiation research [ 0033-7587 ] ; 2014.

RBID : PMC:4101533

Descripteurs français

KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Animaux, Bouche (), Bouche (effets des radiations), Cellules souches hématopoïétiques (), Cellules souches hématopoïétiques (cytologie), Cellules souches hématopoïétiques (effets des radiations), Cou (effets des radiations), Femelle, Fémur (immunologie), Inflammation muqueuse (), Lignée cellulaire, Liposomes, Lésions expérimentales radio-induites (), Moelle osseuse (), Moelle osseuse (effets des radiations), Moelle osseuse (immunologie), Mâle, Numération cellulaire, Oxydes d'azote (administration et posologie), Oxydes d'azote (pharmacologie), Protéine du groupe de complémentation D2 de l'anémie de Fanconi (déficit), Radioprotecteurs (administration et posologie), Radioprotecteurs (pharmacologie), Radiotolérance (), Souris, Tête (effets des radiations).
MESH :
- administration et posologie : Oxydes d'azote, Radioprotecteurs.
- cytologie : Cellules souches hématopoïétiques.
- déficit : Protéine du groupe de complémentation D2 de l'anémie de Fanconi.
- effets des radiations : Bouche, Cellules souches hématopoïétiques, Cou, Moelle osseuse, Tête.
- génétique : ARN messager.
- immunologie : Fémur, Moelle osseuse.
- métabolisme : ARN messager.
- pharmacologie : Oxydes d'azote, Radioprotecteurs.
- Animaux, Bouche, Cellules souches hématopoïétiques, Femelle, Inflammation muqueuse, Lignée cellulaire, Liposomes, Lésions expérimentales radio-induites, Moelle osseuse, Mâle, Numération cellulaire, Radiotolérance, Souris.

English descriptors

KwdEn :
- Animals, Bone Marrow (drug effects), Bone Marrow (immunology), Bone Marrow (radiation effects), Cell Count, Cell Line, Fanconi Anemia Complementation Group D2 Protein (deficiency), Female, Femur (immunology), Head (radiation effects), Hematopoietic Stem Cells (cytology), Hematopoietic Stem Cells (drug effects), Hematopoietic Stem Cells (radiation effects), Liposomes, Male, Mice, Mouth (drug effects), Mouth (radiation effects), Mucositis (prevention & control), Neck (radiation effects), Nitrogen Oxides (administration & dosage), Nitrogen Oxides (pharmacology), RNA, Messenger (genetics), RNA, Messenger (metabolism), Radiation Injuries, Experimental (prevention & control), Radiation Tolerance (drug effects), Radiation-Protective Agents (administration & dosage), Radiation-Protective Agents (pharmacology).
MESH :
- chemical , administration & dosage : Nitrogen Oxides, Radiation-Protective Agents.
- chemical , deficiency : Fanconi Anemia Complementation Group D2 Protein.
- cytology : Hematopoietic Stem Cells.
- drug effects : Bone Marrow, Hematopoietic Stem Cells, Mouth, Radiation Tolerance.
- chemical , genetics : RNA, Messenger.
- immunology : Bone Marrow, Femur.
- chemical , metabolism : RNA, Messenger.
- chemical , pharmacology : Nitrogen Oxides, Radiation-Protective Agents.
- prevention & control : Mucositis, Radiation Injuries, Experimental.
- radiation effects : Bone Marrow, Head, Hematopoietic Stem Cells, Mouth, Neck.
- Animals, Cell Count, Cell Line, Female, Liposomes, Male, Mice.

Abstract

The altered DNA damage response pathway in patients with Fanconi anemia (FA) may increase the toxicity of clinical radiotherapy. We quantitated oral cavity mucositis in irradiated Fanconi anemia Fancd2^−/− mice, comparing this to Fancd2^+/− and Fancd2^+/+ mice, and we measured distant bone marrow suppression and quantitated the effect of the intraoral radioprotector GS-nitroxide, JP4-039 in F15 emulsion. We found that FA mice were more susceptible to radiation injury and that protection from radiation injury by JP4-039/F15 was observed at all radiation doses. Adult 10–12-week-old mice, of FVB/N background Fancd2^−/−, Fancd2^+/− and Fancd2^+/+ were head and neck irradiated with 24, 26, 28 or 30 Gy (large fraction sizes typical of stereotactic radiosurgery treatments) and subgroups received intraoral JP4-039 (0.4 mg/mouse in 100 μL F15 liposome emulsion) preirradiation. On day 2 or 5 postirradiation, mice were sacrificed, tongue tissue and femur marrow were excised for quantitation of radiation-induced stress response, inflammatory and antioxidant gene transcripts, histopathology and assay for femur marrow colony-forming hematopoietic progenitor cells. Fancd2^−/− mice had a significantly higher percentage of oral mucosal ulceration at day 5 after 26 Gy irradiation (59.4 ± 8.2%) compared to control Fancd2^+/+ mice (21.7 ± 2.9%, P = 0.0063). After 24 Gy irradiation, Fancd2^−/− mice had a higher oral cavity percentage of tongue ulceration compared to Fancd2^+/+ mice irradiated with higher doses of 26 Gy (P = 0.0123). Baseline and postirradiation oral cavity gene transcripts were altered in Fancd2^−/− mice compared to Fancd2^+/+ controls. Fancd2^−/− mice had decreased baseline femur marrow CFU-GM, BFUe and CFU-GEMM, which further decreased after 24 or 26 Gy head and neck irradiation. These changes were not seen in head- and neck-irradiated Fancd2^+/+ mice. In radiosensitive Fancd2^−/− mice, biomarkers of both local oral cavity and distant marrow radiation toxicity were ameliorated by intraoral JP4-039/F15. We propose that Fancd2^−/− mice are a valuable radiosensitive animal model system, which can be used to evaluate potential radioprotective agents.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101533

DOI: 10.1667/RR13633.1
PubMed: 24932534
PubMed Central: 4101533

Affiliations:

Le document en format XML

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<sup>−/−</sup>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Amelioration of Radiation-Induced Oral Cavity Mucositis and Distant Bone Marrow Suppression in Fanconi Anemia <italic>Fancd2</italic>
<sup>−/−</sup>
 (FVB/N) Mice by Intraoral GS-Nitroxide JP4-039</title>
<author><name sortKey="Berhane, Hebist" sort="Berhane, Hebist" uniqKey="Berhane H" first="Hebist" last="Berhane">Hebist Berhane</name>
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<author><name sortKey="Kalash, Ronny" sort="Kalash, Ronny" uniqKey="Kalash R" first="Ronny" last="Kalash">Ronny Kalash</name>
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<author><name sortKey="Xu, Karen" sort="Xu, Karen" uniqKey="Xu K" first="Karen" last="Xu">Karen Xu</name>
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<author><name sortKey="Epperly, Michael W" sort="Epperly, Michael W" uniqKey="Epperly M" first="Michael W." last="Epperly">Michael W. Epperly</name>
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<author><name sortKey="Goff, Julie" sort="Goff, Julie" uniqKey="Goff J" first="Julie" last="Goff">Julie Goff</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
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<author><name sortKey="Franicola, Darcy" sort="Franicola, Darcy" uniqKey="Franicola D" first="Darcy" last="Franicola">Darcy Franicola</name>
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<placeName><region type="state">Pennsylvanie</region>
</placeName>
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<author><name sortKey="Zhang, Xichen" sort="Zhang, Xichen" uniqKey="Zhang X" first="Xichen" last="Zhang">Xichen Zhang</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea>
</affiliation>
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<author><name sortKey="Dixon, Tracy" sort="Dixon, Tracy" uniqKey="Dixon T" first="Tracy" last="Dixon">Tracy Dixon</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shields, Donna" sort="Shields, Donna" uniqKey="Shields D" first="Donna" last="Shields">Donna Shields</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea>
</affiliation>
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<author><name sortKey="Wang, Hong" sort="Wang, Hong" uniqKey="Wang H" first="Hong" last="Wang">Hong Wang</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea>
</affiliation>
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<author><name sortKey="Wipf, Peter" sort="Wipf, Peter" uniqKey="Wipf P" first="Peter" last="Wipf">Peter Wipf</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Chemistry, University of Pittsburgh, Pittsburgh</wicri:cityArea>
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<region type="state">Pennsylvanie</region>
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<author><name sortKey="Li, Song" sort="Li, Song" uniqKey="Li S" first="Song" last="Li">Song Li</name>
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<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Greenberger, Joel S" sort="Greenberger, Joel S" uniqKey="Greenberger J" first="Joel S." last="Greenberger">Joel S. Greenberger</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Radiation research</title>
<idno type="ISSN">0033-7587</idno>
<idno type="eISSN">1938-5404</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Bone Marrow (drug effects)</term>
<term>Bone Marrow (immunology)</term>
<term>Bone Marrow (radiation effects)</term>
<term>Cell Count</term>
<term>Cell Line</term>
<term>Fanconi Anemia Complementation Group D2 Protein (deficiency)</term>
<term>Female</term>
<term>Femur (immunology)</term>
<term>Head (radiation effects)</term>
<term>Hematopoietic Stem Cells (cytology)</term>
<term>Hematopoietic Stem Cells (drug effects)</term>
<term>Hematopoietic Stem Cells (radiation effects)</term>
<term>Liposomes</term>
<term>Male</term>
<term>Mice</term>
<term>Mouth (drug effects)</term>
<term>Mouth (radiation effects)</term>
<term>Mucositis (prevention & control)</term>
<term>Neck (radiation effects)</term>
<term>Nitrogen Oxides (administration & dosage)</term>
<term>Nitrogen Oxides (pharmacology)</term>
<term>RNA, Messenger (genetics)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Radiation Injuries, Experimental (prevention & control)</term>
<term>Radiation Tolerance (drug effects)</term>
<term>Radiation-Protective Agents (administration & dosage)</term>
<term>Radiation-Protective Agents (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term>
<term>ARN messager (métabolisme)</term>
<term>Animaux</term>
<term>Bouche ()</term>
<term>Bouche (effets des radiations)</term>
<term>Cellules souches hématopoïétiques ()</term>
<term>Cellules souches hématopoïétiques (cytologie)</term>
<term>Cellules souches hématopoïétiques (effets des radiations)</term>
<term>Cou (effets des radiations)</term>
<term>Femelle</term>
<term>Fémur (immunologie)</term>
<term>Inflammation muqueuse ()</term>
<term>Lignée cellulaire</term>
<term>Liposomes</term>
<term>Lésions expérimentales radio-induites ()</term>
<term>Moelle osseuse ()</term>
<term>Moelle osseuse (effets des radiations)</term>
<term>Moelle osseuse (immunologie)</term>
<term>Mâle</term>
<term>Numération cellulaire</term>
<term>Oxydes d'azote (administration et posologie)</term>
<term>Oxydes d'azote (pharmacologie)</term>
<term>Protéine du groupe de complémentation D2 de l'anémie de Fanconi (déficit)</term>
<term>Radioprotecteurs (administration et posologie)</term>
<term>Radioprotecteurs (pharmacologie)</term>
<term>Radiotolérance ()</term>
<term>Souris</term>
<term>Tête (effets des radiations)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Nitrogen Oxides</term>
<term>Radiation-Protective Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Fanconi Anemia Complementation Group D2 Protein</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Oxydes d'azote</term>
<term>Radioprotecteurs</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules souches hématopoïétiques</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Hematopoietic Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bone Marrow</term>
<term>Hematopoietic Stem Cells</term>
<term>Mouth</term>
<term>Radiation Tolerance</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Protéine du groupe de complémentation D2 de l'anémie de Fanconi</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Bouche</term>
<term>Cellules souches hématopoïétiques</term>
<term>Cou</term>
<term>Moelle osseuse</term>
<term>Tête</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Messenger</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Fémur</term>
<term>Moelle osseuse</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Bone Marrow</term>
<term>Femur</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>RNA, Messenger</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Oxydes d'azote</term>
<term>Radioprotecteurs</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Nitrogen Oxides</term>
<term>Radiation-Protective Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Mucositis</term>
<term>Radiation Injuries, Experimental</term>
</keywords>
<keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Bone Marrow</term>
<term>Head</term>
<term>Hematopoietic Stem Cells</term>
<term>Mouth</term>
<term>Neck</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Count</term>
<term>Cell Line</term>
<term>Female</term>
<term>Liposomes</term>
<term>Male</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Bouche</term>
<term>Cellules souches hématopoïétiques</term>
<term>Femelle</term>
<term>Inflammation muqueuse</term>
<term>Lignée cellulaire</term>
<term>Liposomes</term>
<term>Lésions expérimentales radio-induites</term>
<term>Moelle osseuse</term>
<term>Mâle</term>
<term>Numération cellulaire</term>
<term>Radiotolérance</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The altered DNA damage response pathway in patients with Fanconi anemia (FA) may increase the toxicity of clinical radiotherapy. We quantitated oral cavity mucositis in irradiated Fanconi anemia <italic>Fancd2</italic>
<sup>−/−</sup>
 mice, comparing this to <italic>Fancd2</italic>
<sup>+/−</sup>
 and <italic>Fancd2</italic>
<sup>+/+</sup>
 mice, and we measured distant bone marrow suppression and quantitated the effect of the intraoral radioprotector GS-nitroxide, JP4-039 in F15 emulsion. We found that FA mice were more susceptible to radiation injury and that protection from radiation injury by JP4-039/F15 was observed at all radiation doses. Adult 10–12-week-old mice, of FVB/N background <italic>Fancd2</italic>
<sup>−/−</sup>
, <italic>Fancd2</italic>
<sup>+/−</sup>
 and <italic>Fancd2</italic>
<sup>+/+</sup>
 were head and neck irradiated with 24, 26, 28 or 30 Gy (large fraction sizes typical of stereotactic radiosurgery treatments) and subgroups received intraoral JP4-039 (0.4 mg/mouse in 100 μL F15 liposome emulsion) preirradiation. On day 2 or 5 postirradiation, mice were sacrificed, tongue tissue and femur marrow were excised for quantitation of radiation-induced stress response, inflammatory and antioxidant gene transcripts, histopathology and assay for femur marrow colony-forming hematopoietic progenitor cells. <italic>Fancd2</italic>
<sup>−/−</sup>
 mice had a significantly higher percentage of oral mucosal ulceration at day 5 after 26 Gy irradiation (59.4 ± 8.2%) compared to control <italic>Fancd2</italic>
<sup>+/+</sup>
 mice (21.7 ± 2.9%, <italic>P</italic>
 = 0.0063). After 24 Gy irradiation, <italic>Fancd2</italic>
<sup>−/−</sup>
 mice had a higher oral cavity percentage of tongue ulceration compared to <italic>Fancd2</italic>
<sup>+/+</sup>
 mice irradiated with higher doses of 26 Gy (<italic>P</italic>
 = 0.0123). Baseline and postirradiation oral cavity gene transcripts were altered in <italic>Fancd2</italic>
<sup>−/−</sup>
 mice compared to <italic>Fancd2</italic>
<sup>+/+</sup>
 controls. <italic>Fancd2</italic>
<sup>−/−</sup>
 mice had decreased baseline femur marrow CFU-GM, BFUe and CFU-GEMM, which further decreased after 24 or 26 Gy head and neck irradiation. These changes were not seen in head- and neck-irradiated <italic>Fancd2</italic>
<sup>+/+</sup>
 mice. In radiosensitive <italic>Fancd2</italic>
<sup>−/−</sup>
 mice, biomarkers of both local oral cavity and distant marrow radiation toxicity were ameliorated by intraoral JP4-039/F15. We propose that <italic>Fancd2</italic>
<sup>−/−</sup>
 mice are a valuable radiosensitive animal model system, which can be used to evaluate potential radioprotective agents.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
</region>
<settlement><li>Pittsburgh</li>
</settlement>
<orgName><li>Université de Pittsburgh</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Berhane, Hebist" sort="Berhane, Hebist" uniqKey="Berhane H" first="Hebist" last="Berhane">Hebist Berhane</name>
</region>
<name sortKey="Dixon, Tracy" sort="Dixon, Tracy" uniqKey="Dixon T" first="Tracy" last="Dixon">Tracy Dixon</name>
<name sortKey="Epperly, Michael W" sort="Epperly, Michael W" uniqKey="Epperly M" first="Michael W." last="Epperly">Michael W. Epperly</name>
<name sortKey="Franicola, Darcy" sort="Franicola, Darcy" uniqKey="Franicola D" first="Darcy" last="Franicola">Darcy Franicola</name>
<name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name>
<name sortKey="Goff, Julie" sort="Goff, Julie" uniqKey="Goff J" first="Julie" last="Goff">Julie Goff</name>
<name sortKey="Greenberger, Joel S" sort="Greenberger, Joel S" uniqKey="Greenberger J" first="Joel S." last="Greenberger">Joel S. Greenberger</name>
<name sortKey="Kalash, Ronny" sort="Kalash, Ronny" uniqKey="Kalash R" first="Ronny" last="Kalash">Ronny Kalash</name>
<name sortKey="Li, Song" sort="Li, Song" uniqKey="Li S" first="Song" last="Li">Song Li</name>
<name sortKey="Shields, Donna" sort="Shields, Donna" uniqKey="Shields D" first="Donna" last="Shields">Donna Shields</name>
<name sortKey="Shinde, Ashwin" sort="Shinde, Ashwin" uniqKey="Shinde A" first="Ashwin" last="Shinde">Ashwin Shinde</name>
<name sortKey="Wang, Hong" sort="Wang, Hong" uniqKey="Wang H" first="Hong" last="Wang">Hong Wang</name>
<name sortKey="Wipf, Peter" sort="Wipf, Peter" uniqKey="Wipf P" first="Peter" last="Wipf">Peter Wipf</name>
<name sortKey="Xu, Karen" sort="Xu, Karen" uniqKey="Xu K" first="Karen" last="Xu">Karen Xu</name>
<name sortKey="Zhang, Xichen" sort="Zhang, Xichen" uniqKey="Zhang X" first="Xichen" last="Zhang">Xichen Zhang</name>
</country>
</tree>
</affiliations>
</record>

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Amelioration of Radiation-Induced Oral Cavity Mucositis and Distant Bone Marrow Suppression in Fanconi Anemia Fancd2−/− (FVB/N) Mice by Intraoral GS-Nitroxide JP4-039

Amelioration of Radiation-Induced Oral Cavity Mucositis and Distant Bone Marrow Suppression in Fanconi Anemia Fancd2−/− (FVB/N) Mice by Intraoral GS-Nitroxide JP4-039

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